The protective role of Piper nigrum fruit extract in an ovalbumin-induced allergic rhinitis by targeting of NFκBp65 and STAT3 signalings - 09/12/18
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Graphical abstract |
Highlights |
• | The anti-allergic rhinitis effect of Piper nigrum is investigated. |
• | Piper nigrum ameliorates nasal symptoms and mucosal swelling. |
• | Piper nigrum prevents the activation of STAT3 and NFκBp65 signaling. |
• | Piper nigrum provides a promising strategy for immunotherapy for allergic rhinitis treatment. |
Abstract |
Piper nigrum L. is commonly used as a traditional medicine and food in many countries. It has been reported to have anti-oxidant, anti-bacterial, anti-tumor, anti-mutagenic, anti-diabetic, and anti-inflammatory properties. However, the effect of P. nigrum on allergic rhinitis (AR) has been unclear. In the present study, an OVA-induced AR mice model were established to investigate the anti-allergic, anti-inflammation properties of P. nigrum fruit extract (PNE). Oral administrations of PNE inhibited the allergic nasal symptoms including rubbing and sneezing in the early-phage of AR. In both NALF and nasal tissue, PNE suppressed the inflammatory cells accumulation, specifically with eosinophils in NALF. Additionally, PNE prevented the activation of STAT3 and NFκBp65 signaling in the cytoplasm which led to increasing the synthesis of the anti-inflammatory Th1 cytokines and suppressing the inflammatory Th2, Th17 cytokines. These obtained results suggest that PNE has the promising strategy for immunotherapy in allergic rhinitis disease.
Le texte complet de cet article est disponible en PDF.Abbreviations : PNE, Dex, OVA, PBS, NALF, IL, NFκB, IκBα, STAT3, p-YSTAT3, AR, RORc
Keywords : Piper nigrum, Allergic rhinitis, Eosinophil, STAT3, NFκBp65, Nasal epithelium
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