The applications of anti-CD20 antibodies to treat various B cells disorders - 09/12/18
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Abstract |
B-lymphocyte antigen CD20 (called CD20) is known as an activated-glycosylated phosphoprotein which is expressed on the surface of all B-cells. CD20 is involved in the regulation of trans-membrane Ca2+ conductance and also play critical roles in cell‐cycle progression during human B cell proliferation and activation. The appearance of monoclonal antibody (mAb) technology provided an effective field for targeted therapy in treatment of a variety of diseases such as cancer, and autoimmune diseases. Anti-CD20 is one of important antibodies which could be employed in treatment of several diseases. Increasing evidences revealed that efficacy of different anti-CD20 antibodies is implicated by their function. Hence, evaluation of anti-CD20 antibodies function could provide and introduce new anti-CD20 based therapies. In the present study, we summarized several applications of anti-CD20 antibodies in various immune related disorders including B-CLL (B-cell chronic lymphocytic leukemia), rheumatoid arthritis (RA), multiple sclerosis (MS) and melanoma.
Le texte complet de cet article est disponible en PDF.Keywords : CD20, Monoclonal antibody, B-cell chronic lymphocytic leukemia, Rheumatoid arthritis, Multiple sclerosis, Melanoma
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Vol 109
P. 2415-2426 - janvier 2019 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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