Evaluation of a self-nanoemulsifying docetaxel delivery system - 09/12/18
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Graphical abstract |
Highlights |
• | DTX was loaded into SNEDDS comprising ethyl oleate, Tween 80 and PEG 600. |
• | DTX encapsulation efficiency and loading capacity were determined. |
• | Anticancer efficacy of DTX-loaded SNEDDS was evaluated toward MCF-7 cells. |
• | Pharmacokinetic parameters of DTX-loaded SNEDDS were obtained. |
Abstract |
A self-nanoemulsifying drug delivery system (SNEDDS) was developed as a novel route to enhance the efficacy of docetaxel lipophilic drug. SNEDDS comprised ethyl oleate, Tween 80 and poly(ethylene glycol) 600, as oil, surfactant and co-surfactant, and formed stabilized monodispersed oil nanodroplets upon dilution in water. SNEDDS represented encapsulation efficiency and loading capacity of 21.4 and 52.7%, respectively. The docetaxel release profile from the drug-loaded SNEDDS was recorded, its effectiveness against MCF-7 cell line was investigated, and an IC50 value of 0.98 ± 0.05 μg mL−1 was attained. The drug-loaded SNEDDS was administrated in rats, and the pharmacokinetic parameters of maximum concentration of 22.2 ± 0.8 μg mL-1, time to attain this maximum concentration of 230 min, and area under the curve of 1.71 ± 0.18 μg min mL-1 were obtained. The developed SNEDDS formulation can be represented as an alternative to docetaxel administration.
Le texte complet de cet article est disponible en PDF.Keywords : Taxotere, MCF7 cell, Breast cancer, Nanoemulsion, Anticancer drug
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Vol 109
P. 2427-2433 - janvier 2019 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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