Spirulina ameliorates aspirin-induced gastric ulcer in albino mice by alleviating oxidative stress and inflammation - 09/12/18
, Eman A. Abd El-GhffarBienvenue sur EM-consulte, la référence des professionnels de santé.
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Graphical abstract |
Highlights |
• | Gastric ulcer is a serious effect of prolonged use of aspirin. |
• | Spirulina was reported to have antioxidative and anti-inflammatory effects. |
• | Effect of spirulina on aspirin-induced gastric injury was investigated. |
• | Spirulina attenuated ulcers via antioxidant and anti-inflammatory effects. |
Abstract |
Aspirin is a commonly prescribed non steroidal anti-inflammatory drug, but its prolonged use injures the gastric mucosa. The present study was carried out to evaluate the ameliorative effect of spirulina against aspirin-induced gastric ulcer in albino mice. Gastric ulcer was induced by oral administration of aspirin (500 mg/kg bw). Spirulina (250 and 500 mg/kg bw) was given orally for 3 days after the induction of gastric ulcer. Spirulina ameliorated aspirin-induced gastric ulcer by improving the gross morphology, histology and mucous layer of gastric tissue, augmenting the endogenous enzymatic and non-enzymatic antioxidants (reduced glutathione, glutathione peroxidase, glutathione reductase, superoxide dismutase and catalase) and the cytoprotective marker (COX-1), and by alleviating tissue levels of the lipid peroxidation marker (malondialdehyde) and inflammatory mediators (TNF-α, COX-2 and NO). In conclusion, spirulina has a therapeutic potential in aspirin-induced gastric injury by alleviating oxidative stress and inflammation.
Le texte complet de cet article est disponible en PDF.Keywords : Gastric ulcer, Aspirin, Spirulina, Oxidative stress, Inflammation, Immunohistochemistry
Plan
Vol 109
P. 314-321 - janvier 2019 Retour au numéro
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