Long non-coding RNA DLEU1 exerts an oncogenic function in non-small cell lung cancer - 09/12/18
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Graphical abstract |
Highlights |
• | Long non-coding RNA DLEU1 is up-regulated in NSCLC. |
• | DLEU1 facilitates proliferation, migration, and invasion, but suppresses apoptosis of NSCLC cells. |
• | DLEU1 exerts an oncogenic function in NSCLC both in vitro and in vivo. |
• | DLEU1 regulates CDK1 expression, binds with SRC and alters the expression levels of P70(S6K), MMP2, and E-cadherin. |
Abstract |
Objective |
To explore the role of long non-coding RNA DLEU1 in the tumorigenesis and progression of non-small cell lung cancer (NSCLC) and the underlying mechanisms.
Methods |
The expression of DLEU1 in NSCLC tumor tissues and adjacent normal tissues was evaluated using bioinformatics analysis and qPCR. The effects of DLEU1 overexpression or deficiency on cell proliferation, apoptosis, migration and invasion were explored experimentally. Additionally, the impact of DLEU1 up-regulation on tumourigenesis was also assessed in vivo.
Results |
The expression of DLEU1 was up-regulated in NSCLC tumor tissues. DLEU1 overexpression promoted the proliferation, migration, and invasion, but inhibited the apoptosis of NSCLC cells by upregulating CDK1 expression, binding with SRC and altering the expression of P70(S6K), MMP2 and E-cadherin. Besides, xenograft tumors in nude mice demonstrated that DLEU1 overexpression accelerated tumor growth.
Conclusions |
DLEU1 promoted tumorigenesis and progression of NSCLC, and might be a promising therapeutic target for NSCLC.
Le texte complet de cet article est disponible en PDF.Keywords : DLEU1, Oncogenic function, Non-small cell lung cancer
Plan
Vol 109
P. 985-990 - janvier 2019 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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