Hyperdopaminergic behavioral spectrum in Parkinson's disease: A review - 17/12/18
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Abstract |
Impulse control disorders (ICDs) and other related behaviors, such as punding and dopamine dysregulation syndrome, are frequent yet underrecognized non-motor complications of dopamine replacement therapy (DRT) in Parkinson's disease (PD); they can also have a major negative impact on quality of life. They result from complex interactions between a given individual's predispositions, non-physiological dopaminergic stimulation and PD pathology. Also, sensitization of the mesocorticolimbic pathway, reflected by the psychotropic effects of dopaminergic treatment, plays a crucial role in the emergence of these addictive behaviors. While early detection of changes in behavior, less use of dopamine agonists (DA) that have a relative selectivity for mesocorticolimbic dopamine receptors, and fractionation of levodopa dosages to avoid non-physiological pulsatile stimulation of dopamine receptors are key strategies in the management of this hyperdopaminergic behavioral spectrum, other complementary approaches are also addressed in this review.
Le texte complet de cet article est disponible en PDF.Keywords : Impulse control disorders, Behavioral addictions, Parkinson's disease, Dopamine, Dopamine withdrawal syndrome, Neuropsychiatric fluctuations
Plan
Vol 174 - N° 9
P. 653-663 - novembre 2018 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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