Identification of latent classes of CAV trajectories after heart transplantation and their determinants - 25/12/18
Résumé |
Background |
Cardiac allograft vasculopathy (CAV) remains a major issue associated with increased mortality after heart transplantation (HTx). Prototypes of CAV trajectories including dynamics of progression and associated determinants have not been assessed.
Purpose |
To identify distinct profiles of CAV trajectory following HTx and their determinants.
Methods |
We performed a retrospective multicenter observational study. We included all consecutive patients transplanted between 2004 and 2011 who had at least 2 coronary angiograms during follow-up. We performed an extensive evaluation of potential risk factors that might be associated with CAV. A semi-parametric mixture model was used to identify distinct trajectories of CAV progression from year 1 to year 8 post-transplantation. Multivariable logistic regression model was used to determine risk factors associated with each trajectory.
Results |
Four hundred and forty-six patients met the inclusion criteria. Median follow-up time post transplant was 6.3 years. Three distinct profiles of CAV trajectories were identified: #1-non-progressors (n=280, 62.8%), #2- slow progressors (n=118, 26.5%) and #3- rapid progressors (n=48, 10.8%). Factors independently associated with CAV trajectory #2 were donor age, donor male gender, tobacco consumption of the donor and pre-HTx recipient dyslipidemia. In addition to the previous factors, ischemic etiology of heart failure and the presence of circulating C1q-binding DSA were independent risk factors for CAV trajectory #3.
Conclusion |
In a large and extensively phenotyped cohort of heart transplant recipients, we identified 3 distinct prototypes of CAV trajectories. In addition to traditional cardiovascular risk factors, the presence C1q-binding donor-specific anti-HLA antibodies was associated with an acceleration of CAV.
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Vol 11 - N° 1
P. 15 - janvier 2019 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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