Prosthesis patient mismatch is an independent predictor of congestive heart failure after transcatheter aortic valve replacement - 25/12/18
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Résumé |
Background |
Little is known about the impact of prosthesis-patient mismatch (PPM) on outcomes after trans-catheter aortic valve replacement (TAVR). We reported previously an increased risk of PPM with Sapien 3 transcatheter Heart valve (S3-THV).
Purpose |
We aimed to investigate the one-year outcomes of patients operated on for severe aortic stenosis (AS) with S3-THV based on the occurrence of PPM.
Methods |
Indexed effective orifice area (iEOA) was estimated by post-procedural echocardiography(TTE). PPM was defined as moderate when 0.65cm2≤Ieoa≤0.85cm2, or severe if iEOA<0.65cm2/m2. Inclusion criteria: severe symptomatic AS implanted with S3-THV. Primary endpoint: one-year overall mortality secondary endpoint: hospitalization for congestive heart failure (CHF).
Results |
A total of 227 consecutives patients were included between January 2015 and December 2016. Of the 208 patients with complete follow-up, mean age was 81.9±6, mean Euroscore2 was 4.35±3.4, mean baseline LVEF was 58±13%. At post-procedural TTE, moderate and severe PPM were observed in 69 (33%) and 10 (4.8%) patients respectively. Patients with PPM were younger (80.4±7 vs. 82.9±5, P=0.007), had a larger body surface area (1.84±0.19 vs. 1.77±0.19, P=0.01), a lower iEAO (0.73±0.1 vs. 1.1±0.2, P<0.001) and a higher mean gradient (12±4 vs. 14±5mmHg, P<0.001). At 1 year, the estimated overall mortality was similar between the PPM and non PPM groups (5.1% vs. 5.4%, P=0.97); the PPM group had a significantly higher incidence of CHF at one year follow-up (16.5% vs. 7%, P=0.04). By multivariate analysis, PPM (HR=2.4 [1.02–6], P=0.04) independently predicted CHF whereas LVEF, Paravalvular leakage ≥1, age and male gender did not. By subgroup analysis, patients with MR ≥2 were more vulnerable to PPM as they experienced a prohibitive risk of CHF (HR=51.4 [2.61–99], P=0.006).
Conclusion |
PPM after TAVR with S3-THV is not a risk factor for midterm mortality but is an independent predictor of CHF, especially in the subset of patients with MR ≥2.
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Vol 11 - N° 1
P. 65-66 - janvier 2019 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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