PCAT-1: A pivotal oncogenic long non-coding RNA in human cancers - 06/01/19
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Graphical abstract |
Highlights |
• | PCAT-1 is dysregulated in numerous human cancers. |
• | PCAT-1 is involved in several processes correlated with carcinogenesis. |
• | Molecular basis of the biological role of PCAT-1 is complex. |
Abstract |
Prostate cancer-associated transcript 1 (PCAT-1) is a newly identified long non-coding RNA comprising two exons, located in the Chr8q24 gene desert approximately 725 kb upstream of the MYC oncogene. PCAT-1 is dysregulated and acts as an oncogene in different types of cancers and has been implicated in several processes correlated with carcinogenesis, such as cell proliferation, invasion, metastasis, apoptosis, cell cycle, chemoresistance, and homologous recombination. The mechanisms underlying the effects of PCAT-1 are complex and involve multiple factors and signaling pathways. In this paper, we systematically review the multiple pathological functions of PCAT-1 in diverse malignancies to elucidate its potential molecular mechanisms and to provide new directions for future research.
Le texte complet de cet article est disponible en PDF.Abbreviations : AR, ARE, CeRNA, CRC, CRKL, DHCR24, DSB, ECC, EED, ELAVL1, EZH2, FSCN1, GNMT, HCC, HMGB1, HR, LncRNAs, LSD1, NcRNAs, ONECUT2, PARP, PCAT-1, PRC1/2, SNP, TP53, UTR, WNT1
Keywords : Long non-coding RNA, PCAT-1, Cancer, Oncogene, Prognosis
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Vol 110
P. 493-499 - février 2019 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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