Toxicological evaluation of the biflavonoid, agathisflavone in albino Swiss mice - 06/01/19
pages | 6 |
Iconographies | 3 |
Vidéos | 0 |
Autres | 0 |
Graphical abstract |
Highlights |
• | Agathisflavone (AGF) exhibits important pharmacological and biological activity. |
• | Treatment of mice with high doses of AGF did not significantly change biological parameters. |
• | Results suggest that AGF might be non-toxic in Swiss mice. |
Abstract |
Agathisflavone (AGF) is a biflavonoid with a number of important biological and pharmacological activities, such as antioxidant, antimicrobial, and neuroprotective effects. However, its toxicological effects have not been fully investigated. Accordingly, the aim of this study was to investigate the toxicological effects of AGF in mice. For this purpose, the median lethal dose 50% (LD50) was determined along with the anatomic and histopathological parameters (weight, alimentation, excretion, biochemical, and hematological) in fertile untouched female Swiss mice. Results suggest that during the treatment, no deaths were reported at 300 and 2000 mg/kg (n = 03/group, p.o.). Moreover, AGF did not cause significant change in the above mentioned parameters in test animals when compared with the control group (0.05% Tween 80 dissolved in 0.9% saline). Taken all together, this non-clinical toxicological study revealed that AGF has an LD50 larger than 2000 mg/kg and did not change significantly the hematological, biochemical, histopathological, behavioral, as well as physiological parameters in the female mice.
Le texte complet de cet article est disponible en PDF.Keywords : Agathisflavone, Anacardium occidentale, Toxicological assessment, Open field test
Plan
Vol 110
P. 68-73 - février 2019 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’achat d’article à l’unité est indisponible à l’heure actuelle.
Déjà abonné à cette revue ?