MiR-542-3p, a microRNA targeting CDK14, suppresses cell proliferation, invasiveness, and tumorigenesis of epithelial ovarian cancer - 06/01/19
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Highlights |
• | MiR-542-3p was downregulated in EOC tissue samples and cell lines. |
• | MiR-542-3p suppresses the proliferation of ovarian cancer cells in vitro and in vivo. |
• | MiR-542-3p suppressed cell migration and invasion in vitro. |
• | CDK14 is a direct target of miR-542-3p. |
Abstract |
MicroRNA-542-3p (miR-542-3p) has been implicated in several cancers; however, its precise role in ovarian cancer is unclear. In this study, we found that miR-542-3p was significantly downregulated in epithelial ovarian cancer (EOC) tissues and cell lines. Functional assays showed that overexpression of miR-542-3p suppressed tumor cell proliferation, migration, and invasion in vitro, whereas miR-542-3p knockdown dramatically promoted tumor cell proliferation and invasion. An in vivo assay also revealed that miR-542-3p overexpression significantly attenuated tumor growth. Mechanistically, the gene of cyclin-dependent kinase 14 (CDK14) was identified as a novel target of miR-542-3p. CDK14 overexpression reversed the suppressive effects of miR-542-3p in ovarian cancer cells. Collectively, these results suggest that miR-542-3p functions as a tumor-suppressive miRNA in ovarian cancer by directly targeting CDK14. Our data provide novel insights into potential future treatments for patients with ovarian cancer.
Le texte complet de cet article est disponible en PDF.Keywords : miR-542-3p, Epithelial ovarian cancer, CDK14, Proliferation, Invasion
Plan
Vol 110
P. 850-856 - février 2019 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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