Rosuvastatin attenuates piroxicam-mediated gastric ulceration and hepato-renal toxicity in rats - 06/01/19
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Graphical abstract |
Highlights |
• | Piroxicam-induced gastric ulceration is mediated by lipid peroxidation. |
• | Piroxicam-induced hepatorenal toxicity is mediated by lipid peroxidation. |
• | Rosuvastatin alleviates piroxicam-inflicted gastropathy. |
• | Rosuvastatin alleviates piroxicam-inflicted hepatorenal toxicity. |
• | Rosuvastatin may have therapeutic potential against inflammatory diseases. |
Abstract |
Piroxicam (Px) is a non-steroidal anti-inflammatory drug that is widely prescribed in various inflammatory disorders. However, Px is known to induce gastric ulceration and hepato-renal toxicity. Rosuvastatin (ROSV), a member of the statin family, has anti-inflammatory and antioxidant actions independent of its anti-hyperlipidemic action. Therefore, we investigated the protective effects of ROSV against Px-induced gastric, liver, and kidney injury. Five groups of seven rats each were used; control group, ROSV group (20 mg/kg, given orally), Px group (7 mg/kg, given intraperitoneally), Px+ROSV L (7 and 10 mg/kg, respectively), and Px+ROSV H (7 and 20 mg/kg, respectively) group. The results revealed that Px induced severe gastric mucosal damage expressed by high ulcer index along with significant increases in liver and kidney function parameters including AST, ALT, creatinine, and urea. Disrupted lipid metabolism also was observed in Px-treated animals. Moreover, marked an increase in malondialdehyde (MDA) and decreases in glutathione (GSH) and catalase (CAT) levels along with enhanced activated caspase-3 expression in the gastric, hepatic, and renal tissues following Px-insult suggested a possible involvement of lipid peroxidation in Px-induced gastropathy and hepatorenal toxicity. However, in a dose-dependent manner, ROSV was able to mitigate Px-induced lipid peroxidation and apoptosis in gastric, liver, and kidney tissues.
Le texte complet de cet article est disponible en PDF.Abbreviations : ALT, AST, CAT, COX, DAB, GSH, GSHPx, H2O2, HMG-CoA, MDA, NSAID, O2−, OH, PBS, PI, Px, ROS, ROSV, ROSV L, ROSV H, SOD, UL, UN, US
Keywords : Piroxicam, Rosuvastatin, Gastric ulcer, Hepato-renal toxicity, Lipid peroxidation, Apoptosis
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Vol 110
P. 895-905 - février 2019 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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