A novel resveratrol-curcumin hybrid, a19, attenuates high fat diet-induced nonalcoholic fatty liver disease - 06/01/19
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Highlights |
• | ATR-SEIRAS is applied for in situ exploration of EDC/NHS activation. |
• | EDC/NHS reaction is obviously interfered by phosphate ions in neutral condition (pH = 7.0). |
• | The main contribution is to enable a stable immobilization of bio-recognition elements on developing biosensors. |
Abstract |
Both inflammation and fibrosis are essential in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Taking inflammatory cytokines and signaling pathways as vital mediators, the inhibition of inflammation response may be an effective approach for treating NAFLD. a19, a resveratrol-curcumin hybrid, has been confirmed to exhibit a good anti-inflammatory activity by preventing LPS-induced inflammatory response in macrophages. The study aims to evaluate the protective effect of a19 on high fat diet (HFD)-induced NAFLD. In the present study, compound a19 significantly inhibited the HFD-induced lipid accumulation, liver injury, liver inflammation and fibrosis in mouse model. In vitro, a19 obviously suppressed the expression of PA-induced inflammatory cytokines and fibrosis markers mRNA. Meanwhile, the anti-inflammatory effect of a19 was found to be associated with the inhibition of ERK signal pathway. These results indicated that a19 can be potentially used as a protective agent for NAFLD.
Le texte complet de cet article est disponible en PDF.Abbreviations : PA, NAFLD, NASH, HFD, FFA, BSA, TG, TCH, HDL, LDL, ALT, DMSO, H&E, RT-qPCR
Keywords : Non-alcoholic fatty liver disease, Anti-inflammation, Fibrosis, Curcumin, Resveratrol
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Vol 110
P. 951-960 - février 2019 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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