Ultrasound-Targeted Microbubble Destruction (UTMD) for Localized Drug Delivery into Tumor Tissue - 28/01/19
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Graphical abstract |
Highlights |
• | UTMD is used for non-invasive localized drug delivery. |
• | Microbubbles serve as excellent cavitation nuclei. |
• | Stable and inertial UTMD cavitation effects contribute to tissue permeabilization. |
• | Drug carriers can be co-injected or directly coupled to microbubbles. |
• | A first clinical trial confirmed therapeutic efficacy in pancreatic cancer patients. |
Abstract |
Background |
Ultrasound-targeted microbubble destruction (UTMD) is a type of ultrasound therapy, in which low frequency moderate power ultrasound is combined with microbubbles to trigger cavitation. Cavitation is the process of oscillation of gas bubbles causing biophysical effects such as pushing and pulling or shock waves that permeabilize biological barriers. In vivo, cavitation results in tissue permeabilization and is used to enable local delivery of nanomedicine. While cavitation can occur in biological liquids when high pressure ultrasound is applied, the use of microbubbles as cavitation nuclei in UTMD largely facilitates the induction of cavitation. UTMD is intensively studied for drug delivery into tumor tissue, but also for the activation of anti-tumor immune responses. The first clinical studies of UTMD-mediated chemotherapy delivery confirmed safety and efficacy of this approach.
Aim |
The present review summarizes ultrasound settings, cavitation approaches, biophysical mechanisms of drug delivery, drug carriers, and pre-clinical and clinical applications of UTMD for drug delivery into tumors.
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Vol 40 - N° 1
P. 10-15 - février 2019 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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