A nomogram to identify high-risk melanoma patients with a negative sentinel lymph node biopsy - 11/02/19
, Mariana Petaccia de Macedo, MD, PhD b, Vinícius Fernando Calsavara, PhD c, Clovis Antonio Lopes Pinto, MD, PhD b, João Pedreira Duprat Neto, MD, PhD aAbstract |
Background |
Melanoma patients with negative nodes after sentinel lymph node biopsy are a heterogeneous group. Current guidelines fail to adequately stratify surveillance and treatment for this group. Also, there is scarce data on adjuvant treatments for these patients.
Objective |
To create a nomogram including clinical and pathologic characteristics capable of evaluating the risk for recurrence of primary melanoma patients with negative sentinel lymph node biopsies (SLNBs).
Methods |
We used a retrospective cohort of patients who underwent SLNB during 2000-2015 at a single institution.
Results |
Our cohort comprised 1213 patients. Among these patients, 967 (79.7%) had a negative SLNB, and mean follow-up was 59.67 months. There were 133 recurrences (13.8%); 45 (33.8%) presented with nodal recurrence, and 35 (26.3%) recurred where a SLNB was performed. Breslow thickness, ulceration, and microsatellitosis were found to be predictive of risk for recurrence at 1, 2, 5, and 10 years.
Limitation |
Single center analysis.
Conclusion |
We created a predictive nomogram for melanoma patients with negative SLNBs. This nomogram is easy to use and identifies high-risk patients who should have more strict surveillance and be considered for adjuvant treatment.
Le texte complet de cet article est disponible en PDF.Key words : melanoma, nomograms, recurrence, sentinel lymph node biopsy
Abbreviation used : SLNB
Plan
| Funding sources: None. |
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| Conflicts of interest: None disclosed. |
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| Reprints not available from the authors. |
Vol 80 - N° 3
P. 722-726 - mars 2019 Retour au numéro
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