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Smoking, but not alcohol, is associated with risk of psoriasis in a Taiwanese population-based cohort study - 11/02/19

Doi : 10.1016/j.jaad.2018.11.015 
Ying-Xiu Dai, MD a, b, Shih-Chun Wang, MSc c, Yiing-Jenq Chou, MD, PhD c, Yun-Ting Chang, MD, PhD a, b, Tzeng-Ji Chen, MD, PhD b, d, Chung-Pin Li, MD, PhD b, e, Chen-Yi Wu, MD, PhD a, b, c,
a Department of Dermatology, Taipei Veterans General Hospital, Taipei, Taiwan 
d Department of Family Medicine, Taipei Veterans General Hospital, Taipei, Taiwan 
e Division of Gastroenterology and Hepatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan 
b School of Medicine, National Yang-Ming University, Taipei, Taiwan 
c Institute of Public Health and Department of Public Health, National Yang-Ming University, Taipei, Taiwan 

Correspondence to: Chen-Yi Wu, MD, PhD, Department of Dermatology, Taipei Veterans General Hospital, Taipei, Taiwan, No 201, Section 2, Shih-Pai Road, Taipei 112, Taiwan.Department of DermatologyTaipei Veterans General Hospital, Taipei, TaiwanNo 201Section 2Shih-Pai RoadTaipei112Taiwan

Abstract

Background

Alcohol consumption and smoking have long been suspected of increasing the risk of developing psoriasis. Most evidence to date has derived from cross-sectional or case-control studies.

Objective

We sought to investigate the effects of alcohol and smoking on incident psoriasis.

Methods

Alcohol consumption, smoking status, and other covariates were collected from four rounds (2001, 2005, 2009, and 2013) of the Taiwan National Health Interview Survey. Incident psoriasis was identified from the National Health Insurance database. Cox regression model was used for the analysis.

Results

Of 60,136 subjects, 242 (0.40%) developed psoriasis. After controlling for demographics and comorbidities, alcohol consumption was not significantly associated with psoriasis risk. Conversely, psoriasis risk was higher for current smokers than never smokers (adjusted hazard ratio 1.47 [95% confidence interval 1.04-2.07]). The risks were higher among subjects who smoked >25 cigarettes per day and for >20 pack-years. In subgroup analysis, current smoking was significantly associated with risk of psoriasis without psoriatic arthritis but not psoriatic arthritis alone.

Limitations

Alcohol consumption was not assessed based on the number of drinks consumed.

Conclusion

Current smoking increased the risk of psoriasis, particularly augmented for individuals who smoked >25 cigarettes per day and for >20 pack-years, while alcohol consumption was not significantly associated with psoriasis development.

Le texte complet de cet article est disponible en PDF.

Key words : alcohol, cohort study, psoriasis, smoking

Abbreviations used : aHR, BMI, HR, ICD-9-CM, NHIRD, NHIS, PsA


Plan


 Supported by grants from the Ministry of Science and Technology, Republic of China (MOST 104-2314-B-075-044-MY2) and the Taipei Veterans General Hospital (V106C-085).
 Conflicts of interest: None disclosed.


© 2018  American Academy of Dermatology, Inc.. Publié par Elsevier Masson SAS. Tous droits réservés.
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Vol 80 - N° 3

P. 727-734 - mars 2019 Retour au numéro
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