Daphnoretin: An invasion inhibitor and apoptosis accelerator for colon cancer cells by regulating the Akt signal pathway - 16/02/19
, Xin Gao c, Meng Li a, Honglei Bian aBienvenue sur EM-consulte, la référence des professionnels de santé.
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Highlights |
• | Daphnoretin could suppress the cell activity of colon cancer cell line HCT116. |
• | Daphnoretin could suppress proliferation, induce apoptosis, and inhibit metastasis/invasion of HCT116 cells. |
• | Daphnoretin could inhibit the activity of colon cancer cells by regulating Akt signal pathway. |
Abstract |
The regulation of Daphnoretin on specific tumours (e.g. cervical cancer, lung cancer, osteosarcoma) has been documented, which still remains unclear for colon cancer cells. Our study explored the suppression of Daphnoretin and its molecular mechanism on the proliferation, apoptosis, invasion and migration of human colon cancer cell line HCT116. Our report showed the activity of HCT116 declined with time- and dose- dependence after Daphnoretin intervention, and a rise in G0/G1 ratio and decrease in G2/M ratio was observed. Daphnoretin-treated HCT116 had declined invasion and migration, increased apoptosis rate, and variations in gene expressions related to the Akt signal pathway. Those results indicated that Daphnoretin can inhibit the proliferation, invasion, and migration of HCT116 and promote its apoptosis by regulating the activity of Akt signal pathway.
Le texte complet de cet article est disponible en PDF.Keywords : Colon cancer, Daphnoretin, Apoptosis, Invasion, AKT signal pathway
Plan
Vol 111
P. 1013-1021 - mars 2019 Retour au numéro
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