The roles of circular RNAs in human development and diseases - 16/02/19
, Safa Abdelgadir Mohamed Elhassan b , Grace Pei Ling Lim a , Weng Hong Kok a , Sze Wei Tan a , Ee Neng Leong a , Sean Hong Tan a , Elaine Wan Ling Chan d , Subrat Kumar Bhattamisra c , Ramkumar Rajendran c, ⁎ , Mayuren Candasamy c, ⁎ Bienvenue sur EM-consulte, la référence des professionnels de santé.
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| pages | 11 |
| Iconographies | 3 |
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Graphical abstract |
Highlights |
• | cirRNAs are formed through back-slicing of pre-mRNA and can function as microRNA sponges. |
• | cirRNAs are resistant to exoribonucleases and are highly stable due to their circular structure. |
• | circRNAs could regulate organogenesis with an independent function to their expressed genes. |
• | cirRNAs play important roles in the development of human diseases and could be developed as biomarkers in disease diagnosis and treatment. |
Abstract |
For many years, circular ribonucleic acids (circRNAs) have been counted as aberrant splicing by-products. Advanced bioinformatics analysis and deep sequencing techniques have allowed researchers to discover more interesting facts about circRNAs. Intriguing evidence has shed light on the functions of circRNAs in many tissues. Furthermore, emerging reports showed that circRNAs are found abundantly in saliva and blood samples, suggesting that circRNAs are potential clinical biomarkers for human embryonic development, diseases progression and prognosis, in addition to its role in organogenesis and pathogenesis. The implementation of circRNAs in human developmental stages and diseases would be a tremendous discovery in the science and medical field. Therefore, circRNAs have been studied for its biological function as well as its implication in various human diseases. The aim of this review is to highlight the importance of circRNAs in cardiac, respiratory, nervous, endocrine and digestive systems. In addition, the role and impact of circRNAs in, cardiogenesis, neurogenesis and cancer have been discussed.
Le texte complet de cet article est disponible en PDF.Keywords : Circular RNAs, Organogenesis, Development, Biomarkers, Diseases, Systems
Plan
Vol 111
P. 198-208 - mars 2019 Retour au numéro
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