Acute and sub-acute toxicity study of hydro-alcoholic leaves extract of Reinwardtia indica in rats - 16/02/19
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Abstract |
The present study was to assess the toxicity of hydro alcoholic leaves extract of Reinwardtia indica in Charles foster rats through an acute and sub-acute study. In the acute study, rats were treated orally with single dose and for sub-acute study different doses were given orally for 28 consecutive days. At the dose of 2000 mg/kg satellite group was also used for 6 weeks as per OECD guidelines-407. General behavioral parameters were assessed in acute toxicity and found no mortality or exterior signs of toxicity. While in the sub-acute study; biochemical, hematological and histopathology along with the body weight, food, and water consumptions parameters were screened in the animals after 14 & 28 days. The study reveals the insignificant (P < 0.05) change in treated group in comparison to the control. The hydroalcoholic leaves extract of Reinwardtia indica was found non-toxic up to 5000 mg/kg in acute study whereas up to 2000 mg/kg dose level in the sub-acute study.
Le texte complet de cet article est disponible en PDF.Keywords : Reinwardtia indica, Hematological test, Histopathology
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Vol 111
P. 36-41 - mars 2019 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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