Tendon thickening in dialysis-related joint arthritis is due to amyloid deposits at the surface of the tendon - 02/03/19
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Highlights |
• | MRI shows a combination of amyloid deposits in the synovium and tendons. |
• | Bone erosions and the thickening of the tendon are the most common lesions in DRA. |
• | Special awareness should be drawn by the thickening of the tendon particularly in the spine. |
• | MRI is useful to better achieve the diagnosis of β2 microglobulin dialysis-related amyloidosis. |
Abstract |
Objectives |
Beta-2-microglobulin (β2M) dialysis-related amyloidosis (DRA), a disabiliting joint disease, has been initially reported in patients under long-term dialysis. The incidence and prevalence has significantly decreased with the improvement in dialysis techniques. Here, we attempted to clarify the clinical and MRI features to improve the diagnosis.
Methods |
We retrospectively reviewed the files of 19 patients under dialysis treatment referred for suspicion of β2M DRA. The diagnosis was based on MRI criteria (low signal intensity on both T1- and T2-weighted MR sequences). MRI analysis included a scoring of the several joint lesions. Scores were quantified according to a severity scale (0 to 3).
Results |
Patients had a mean age of 66.0 ± 10.5 years and mean dialysis duration of 23.7 ± 10.5 years. DRA affected mainly large joints (shoulder in 73.7%, hip in 47.3%) and spine (36.8%). MRI images for 8 shoulders, 8 hips, and 3 spines were analysed. Amyloid synovitis was present in all cases, with high mean scores in the three sites. In all joints, the most common lesions were tendon thickening (68.4%) and bone erosions (68.4%). The mean tendon thickening score was high, particularly at the shoulders and also at the spine. Bone erosions were most frequent in the shoulder and pelvis.
Conclusion |
In patients under long-term dialysis, β2M DRA involves large joints but also the spine. Special awareness should be drawn by the thickening of the tendon. MRI is required to characterize the pattern of the lesions and to achieve the diagnosis.
Le texte complet de cet article est disponible en PDF.Keywords : 2-microglobulin, Dialysis, Amyloidosis, Arthropathy, Magnetic resonance imaging
Plan
Vol 86 - N° 2
P. 233-238 - mars 2019 Retour au numéro
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