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Increased risk for incident thyroid diseases in people with psoriatic disease: A cohort study - 14/03/19

Doi : 10.1016/j.jaad.2018.11.049 
Shu-Hui Wang, MD, MS a, b, Jui Wang, MPH c, Yu-Sheng Lin, MD d, e, Tao-Hsin Tung, PhD f, , Ching-Chi Chi, MD, MMS, DPhil, FAAD g, h,
a Department of Dermatology, Far Eastern Memorial Hospital, New Taipei City, Taiwan 
b Graduate Institute of Applied Science and Engineering, College of Science and Engineering, Fu Jen Catholic University, New Taipei City, Taiwan 
c Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan 
d Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital, Chiayi, Taiwan 
e Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan 
f Department of Medical Research and Education, Cheng Hsin General Hospital, Taipei, Taiwan 
g Department of Dermatology, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan 
h College of Medicine, Chang Gung University, Taoyuan, Taiwan 

Reprint requests: Ching-Chi Chi, MD, MMS, DPhil, FAAD, Department of Dermatology, Chang Gung Memorial Hospital, Linkou, 5, Fuxing St, Guishan Dist, Taoyuan 33305, Taiwan.Department of DermatologyChang Gung Memorial HospitalLinkou, 5, Fuxing StGuishan DistTaoyuan33305Taiwan∗∗Tao-Hsin Tung, PhD, Department of Medical Research and Education, Cheng Hsin General Hospital, 45, Cheng Hsin St, Pai-Tou, Taipei 11220, Taiwan.Department of Medical Research and EducationCheng Hsin General Hospital45, Cheng Hsin StPai-TouTaipei11220Taiwan

Abstract

Background

The association between psoriasis and thyroid diseases is unclear.

Objective

To examine the risk for thyroid diseases among psoriasis patients.

Methods

We used Taiwan's National Health Insurance Research Database to conduct a nationwide cohort study. We examined the adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs) for incident thyroid diseases in relation to psoriasis and psoriatic arthritis.

Results

We identified 13,266 patients with psoriatic arthritis (psoriatic arthritis group), 149,576 with psoriasis alone (psoriasis group), and 162,842 nonpsoriasis controls. Compared with the nonpsoriasis controls, the psoriatic arthritis and psoriasis groups had increased risk for incident hyperthyroidism (aHR 1.32, 95% CI 1.07-1.65 [psoriatic arthritis]; aHR 1.22, 95% CI 1.11-1.33 [psoriasis]) and Graves disease (aHR 1.38, 95% CI 1.07-1.79 [psoriatic arthritis]; aHR 1.26, 95% CI 1.13-1.41 [psoriasis]). Both groups also had increased risk for incident hypothyroidism (aHR 1.74, 95% CI 1.34-2.27 [psoriatic arthritis]; aHR 1.38, 95% CI 1.23-1.56 [psoriasis]) and Hashimoto thyroiditis (aHR 2.09, 95% CI 1.34-3.24 [psoriatic arthritis]; aHR 1.47, 95% CI 1.18-1.82 [psoriasis]).

Limitations

Lack of data on psoriasis severity.

Conclusion

People with psoriatic disease are associated with an increased incident thyroid diseases, including hyperthyroidism, hypothyroidism, thyroiditis, Graves disease, and Hashimoto thyroiditis. Endocrinology consultation may be considered when psoriasis patients present with thyroid symptoms.

Le texte complet de cet article est disponible en PDF.

Key words : cohort study, hyperthyroidism, hypothyroidism, National Health Insurance Research Database, psoriasis, psoriatic arthritis, thyroid diseases

Abbreviations used : aHR, CI, HR, ICD-9-CM, LHID, NHIRD


Plan


 Funding sources: Supported by the Far Eastern Memorial Hospital (FEMH-2017-C-021), Taiwan.
 Conflicts of interest: None disclosed.


© 2018  American Academy of Dermatology, Inc.. Publié par Elsevier Masson SAS. Tous droits réservés.
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Vol 80 - N° 4

P. 1006-1012 - avril 2019 Retour au numéro
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