Intravenous infusion of glucose 5% despite sodium mixed, is main contributor of acquired hyponatremia in adult polyvalent medicine service: Case control study - 04/04/19
, Nalia Dibambou, Emeline-Gracia Mouendou Mouloungui, Josaphat Iba-Ba, Ulrich Davy Kombila, Patrice-Emery Itoudi Bignoumba, Inès-Flore Maganga Moussavou, Landry Missounga, Jean-Baptiste Moussavou Kombila, Jean-Bruno BoguikoumaAbstract |
Background |
Acquired hyponatremia is a life threatening event. Intravenous infusion of a mixture of 5% glucose and sodium solute is mainly used, but its contribution in the occurrence of acquired hyponatremia in adult, is under-investigated outside intensive care unit.
Objective |
To evaluate the place of intravenous infusion of a mixture of 5% glucose and sodium in predicting acquired hyponatremia in adult polyvalent medicine service.
Patients and methods |
A case-control study have been conducted. The main exposure was intravenous infusion of a mixture of 5% glucose and sodium solute (4 grams NaCl/liter of 5% glucose).
Outcome |
Acquired hyponatremia during hospitalization. By logistic regression, the global multifactorial model predicting acquired hyponatremia, and its sub-models were established; as well as following parameters: area under the Receiving Operator Characteristic curve (AUC), maximal Youden's index with its couple of coordinates (sensibility-specificity), Nagelkerke's R-squared adjusted.
Results |
Adjusted odds ratio (cases/controls; main exposure; outcome) ORa=2.73 (95% CI 1.40–5.32; P=0.003). Prediction of acquired hyponatremia: global multifactorial model: AUC=0.78 (95% CI 0.72–0.85; P<0.0001), Youden's index=0.34 (95% CI 0.24–0.41); sub-model (global multifactorial model without main exposure): AUC=0.72 (95% CI 0.66–0.78; P<0.0001), Youden's index=0.18 (95% CI 0.07–0.22).
Conclusion |
Intravenous infusion of a mixture of 5% glucose and sodium mainly used, highly contribute to predict acquired hyponatremia in adult polyvalent medicine service, and should be the first cause to consider for managing this acquired hyponatremia.
Le texte complet de cet article est disponible en PDF.Keywords : Acquired hyponatremia, Adult polyvalent medicine, Glucose solute 5%, Intravenous infusion
Plan
Vol 15 - N° 2
P. 91-96 - avril 2019 Retour au numéro
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