Acquired disorders with hypopigmentation: A clinical approach to diagnosis and treatment - 12/04/19

Doi : 10.1016/j.jaad.2018.07.070

Mohammed D. Saleem, MD, MPH ^a,^⁎ , Elias Oussedik, MD ^b, Mauro Picardo, MD, PhD ^c, Jennifer J. Schoch, MD ^d,^e
^a Department of Internal Medicine, University of Florida College of Medicine and University of Florida Health, Gainesville, Florida
^b McGill University, Montreal, Quebec, Canada
^c Department of Dermatology and Pediatric Dermatology, Cutaneous Physiopathology and Integrated Center of Metabolomics Research, San Gallicano Dermatologic Institute, IRCCS, Rome, Italy
^d Department of Dermatology, University of Florida, Gainesville, Florida
^e Department of Pediatrics, University of Florida, Gainesville, Florida

^∗Correspondence to: Mohammed D. Saleem, MD, MPH, University of Florida College of Medicine, PO Box 100277, Gainesville, FL 32610-0277.University of Florida College of MedicinePO Box 100277GainesvilleFL32610-0277

Abstract

Acquired hypopigmented skin changes are commonly encountered by dermatologists. Although hypopigmentation is often asymptomatic and benign, occasional serious and disabling conditions present with cutaneous hypopigmentation. A thorough history and physical examination, centered on disease distribution and morphologic findings, can aid in delineating the causes of acquired hypopigmented disorders. The second article in this 2-part continuing medical education series focuses on conditions with a hypopigmented phenotype. Early diagnosis and appropriate management of these disorders can improve a patient's quality of life, halt disease progression, and prevent irreversible disability.

Le texte complet de cet article est disponible en PDF.

Key words : arsenicosis, Bier spots, chronic arsenic exposure, copper deficiency, cutaneous T-cell lymphoid dyscrasia, drug-induced hypopigmentation, eruptive hypomelanosis, global hypopigmentation, hypopigmented mycosis fungoides, hypopigmented parapsoriasis en plaque, idiopathic guttate hypomelanosis, leprosy, leucoderma syphiliticum, leukoderma punctata, nutritional deficiencies, physiological anemic macules, pityriasis versicolor, postinflammatory hypopigmentation, progressive macular hypomelanosis, post–kala-azar dermal leishmaniasis, selenium deficiency

Plan

	Funding sources: None.
	Reprints not available from the authors.
	Date of release: May 2019
	Expiration date: May 2022
	Conflicts of interest: None disclosed.