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Cutaneous nevi and risk of melanoma death in women and men: A prospective study - 12/04/19

Doi : 10.1016/j.jaad.2018.12.058 
Wen-Qing Li, PhD a, b, c, , Eunyoung Cho, ScD b, c, d, Martin A. Weinstock, MD b, c, e, Suyun Li, PhD b, f, Meir J. Stampfer, MD, DrPH d, g, h, Abrar A. Qureshi, MD, MPH b, c, d
a Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Cancer Epidemiology, Peking University Cancer Hospital and Institute, Beijing, China 
b Department of Dermatology, Warren Alpert Medical School, Brown University, Providence, Rhode Island 
c Department of Epidemiology, School of Public Health, Brown University, Providence, Rhode Island 
d Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 
e Center for Dermatoepidemiology, VA Medical Center, Providence, Rhode Island 
f School of Public Health, Institute for Chemical Carcinogenesis, Guangzhou Medical University, Guangzhou, China 
g Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts 
h Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts 

Correspondence to: Wen-Qing Li, PhD, Brown University, 339 Eddy St, Providence, RI 02903.Brown University339 Eddy StProvidenceRI02903

Abstract

Background

It was unclear whether an increased number of common nevi (moles) predicts melanoma death.

Objective

We prospectively examined the association between number of common nevi and risk of melanoma death.

Methods

Our study used data from the Nurses' Health Study (n = 77,288 women) and Health Professionals Follow-up Study (n = 32,455 men). In 1986, participants were asked about the number of moles they had with a ≥3-mm diameter on the upper extremity, and we stratified their answers into 3 categories (none, 1-2, or ≥3) on the basis of data distribution.

Results

During follow-up (1986-2012), 2452 melanoma cases were pathologically confirmed; among these, we identified 196 deaths due to melanoma. Increased number of nevi was associated with melanoma death; the hazard ratio (HR) for ≥3 nevi compared with no nevi was 2.49 (95% confidence interval [CI] 1.50-4.12) for women and 3.97 (95% CI 2.54-6.22) for men. Among melanoma cases, increased number of nevi was associated with melanoma death in men (≥3 nevi, HR 1.89, 95% CI 1.17-3.05) but not in women. Similarly, the number of nevi was positively associated with Breslow thickness in men only (Ptrend = .01).

Limitations

This is an epidemiologic study without examination into mechanisms.

Conclusion

Increased number of cutaneous nevi was significantly associated with melanoma death. High nevus count might serve as an independent prognostic factor to predict the risk of melanoma death particularly among male melanoma patients.

Le texte complet de cet article est disponible en PDF.

Key words : Breslow thickness, cohort study, common nevi, death, melanoma

Abbreviations used : CI, HPFS, HR, NHS, SD


Plan


 Funding sources: Supported by the Research Career Development Award of the Dermatology Foundation and National Institutes of Health grants for the Nurses' Health Study (P01 CA87969 and UM1 CA186107), Nurses' Health Study II (UM1 CA176726), and Health Professionals Follow-up Study (UM1 CA167552).
 Previously presented as a poster at the American Association for Cancer Research 2017 meeting in Washington, DC, April 1-5, 2017, and the Society for Investigative Dermatology 2017 meeting in Portland, Oregon, April 26-29, 2017.
 Conflicts of interest: None disclosed.
 Disclaimer: The views presented in this manuscript do not necessarily represent the views of the Department of Veteran Affairs. Funding sources had no role in the study design and conduct; collection, management, analysis, and interpretation of data; preparation, review, or approval of the report; or decision to submit the article for publication.
 Reprints not available from the authors.


© 2019  American Academy of Dermatology, Inc. Tous droits réservés.
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Vol 80 - N° 5

P. 1284-1291 - mai 2019 Retour au numéro
Article précédent Article précédent
  • Retrospective single-center study evaluating clinical and dermoscopic features of longitudinal melanonychia, ABCDEF criteria, and risk of malignancy
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  • Lauren C. Strazzulla, Xiaoxue Li, Kathleen Zhu, Jean-Phillip Okhovat, Sandra J. Lee, Caroline C. Kim

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