The impact of HCG in IVF Treatment: Does it depend on age or on protocol? - 19/04/19
, Vasilios Athanasiou b, e , Emmanouela Liokari c , Sofoklis Stavrou a, c , Maria Sakellariou b , Antonia-Iliana Athanassiou d , Adamantios Athanassiou b , Petros Drakakis a, c , Dimitris Loutradis a, c, ⁎ Bienvenue sur EM-consulte, la référence des professionnels de santé.
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Abstract |
Objective |
to evaluate the effect of the addition of low dose human chorionic gonadotropin (hCG) to human menopausal gonadotropin (HMG) throughout the early follicular phase in controlled ovarian stimulation (COS) conducted with two difference regimens. Gonadotropin-releasing hormone (GnRH) antagonist and short GnRH-agonist protocol were applied in two in vitro fertilization (IVF) clinics.
Methods |
Clinical study conducted during the period 2014–2016 in two IVF clinics in a cohort of 240 women. In the first group 1 (124 women), a GnRH antagonist protocol with HMG and addition of low dose (100IU/day) h CG was applied. The other group 2 consisted of 116 women who underwent a short GnRH- agonist protocol with HMG and addition of low dose (100IU/day) h CG.
Results |
Multiple logistic regression analysis was performed. The group 2 found to be associated with greater number of follicles and oocytes. The pregnancy rates were 12.1% and 26.7% in group 1 and group 2, respectively (p=0.004). For patients over 40 years, the number of follicles and oocytes retrieved were significant higher in group 2.The pregnancy rate in group 2 was higher than in group 1 (21, 6% vs 5%, p=0.017).
Conclusions |
Advanced age women are likely to achievepregnancy using the GnRH Short than GnRH antagonist, when HMG/hCG is used, while HMG–hCG gonadotropins have the same potentialas Recombinant follicle stimulating hormone (rFSH)–hCG used in GnRH short protocol.
Le texte complet de cet article est disponible en PDF.Keywords : Low-Dose Human Chorionic Gonadotropin, Human menopausal gonadotropin, Gonadotropin-releasing hormone antagonist, Short GnRH-agonist protocol, In vitro fertilization
Plan
Vol 48 - N° 5
P. 341-345 - mai 2019 Retour au numéro
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