Nephrotoxicity associated with herbal medicine use, experience from Morroco - 03/05/19

Doi : 10.1016/j.toxac.2019.04.001

Noufissa Touiti ^a,^b,^⁎ , Sanae Achour ^a,^c,^d, Imane Iken ^a,^c,^d, Mohamed Chebaibi ^a,^b, Tarik Sqalli Houssaini ^e
^a Research Team “Toxicology and Environmental Health” Center of Biomedical and Translational Research, Hospital University Hassan II, Fez, Morocco
^b Sciences and Technologies faculty, University Sidi Mohammed Ben Abdellah, Fez, Morocco
^c Laboratory of Toxicology, Hospital University Hassan II, Fez, Morocco
^d Faculty of Medicine and Pharmacy of Fez, University Sidi Mohammed Ben Abdellah, Fez, Morocco
^e Research Team “Kidney” Laboratory of Molecular Bases in Human Pathology and Therapeutic Tools, Hospital University Hassan II, Fez, Morocco

^⁎Corresponding author. Research Team “Toxicology and Environmental Health” Center of Biomedical and Translational Research, Hospital University Hassan II, Fez, Morocco.Research Team “Toxicology and Environmental Health” Center of Biomedical and Translational Research, Hospital University Hassan IIFezMorocco

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Summary

Aims

To study the incidence of nephrotoxicity associated with the use of plants in the nephrology department of hospital university Hassan II Fez, Morocco.

Methods

This was a prospective study of plants use by patients with kidney disease. Medical records of patients with kidney disease who consumed plants that could be nephrotoxic were reviewed. Information about age, sex, etiology, and bio-data were collected.

Results

The incidence of nephrotoxicity related to plants use was 3% (18/600) of all the patients with nephropathy coming to the department during the study period. The most plants incriminated in the nephrotoxicity according to the study were: Aristolochia longa, Herniaria Hirsuta, Artemisia herba alba asso, and Cassia senna.

Conclusion

The use of plants by patients with kidney disease may promote or aggravate pre-existing kidney disease. Hence, the value of monitoring the phytovigilance system.

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Keywords : Nephrotoxicity, Herbal medicine, Kidney disease, Morocco