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Circulating retinol-binding protein 4 is associated with the development and regression of non-alcoholic fatty liver disease - 10/05/19

Doi : 10.1016/j.diabet.2019.04.009 
Xu Wang a, b, Xu Chen a, b, Hanyue Zhang a, b, Juan Pang a, b, Jiesheng Lin b, c, Xiping Xu d, Lili Yang a, b, d, Jing Ma a, b, Wenhua Ling a, b, d, , Yuming Chen b, c, d
a Department of Nutrition, School of Public Health, Sun Yat-Sen University, Guangzhou 510080, Guangdong Province, P. R. China 
b Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Guangzhou 510080, Guangdong Province, P. R. China 
c Department of Medical Statistics & Epidemiology, School of Public Health, Sun Yat-Sen University, Guangzhou 510080, Guangdong Province, P. R. China 
d Guangdong Engineering Technology Center of Nutrition Transformation, Guangzhou 510080, Guangdong Province, P. R. China 

Corresponding authors: Department of Nutrition, School of Public Health, Sun Yat-Sen University, 74 Zhongshan Road 2, Guangzhou, Guangdong Province, 510080, P.R. ChinaDepartment of NutritionSchool of Public HealthSun Yat-Sen University74 Zhongshan Road 2GuangzhouGuangdong Province510080P.R. China
Sous presse. Manuscrit accepté. Disponible en ligne depuis le vendredi 10 mai 2019

Abstract

Aim. – Retinol-binding protein 4 (RBP4), primarily secreted by liver and adipose tissue, has been linked with non-alcoholic fatty liver disease (NAFLD). However, investigations on the relationships between RBP4 and NAFLD have produced inconsistent results. Therefore, the association between serum RBP4 levels and the development or regression of NAFLD was prospectively investigated.

Methods. – A total of 3389 Chinese adults, aged 40–75 years and followed-up for 3.09 years, were included and analyzed in the study. NAFLD was diagnosed by abdominal ultrasonography. Serum RBP4 levels were measured, and their relationship to NAFLD development and regression assessed.

Results. – Of the 1318 participants without NAFLD at baseline, 410 developed NAFLD after follow-up. Baseline RBP4 was positively associated with incident NAFLD: the fully adjusted odds ratio (OR) was 2.01 with a 95% confidence interval (CI) of 1.33–3.04 (P = 0.003 for trend). After follow-up, a significant increase in RBP4 levels was observed in participants who developed NAFLD. On the other hand, in 1382 subjects diagnosed with NAFLD at baseline, 339 experienced NAFLD regression after follow-up. Thus, baseline RBP4 was inversely associated with NAFLD regression: the fully adjusted OR was 0.52, 95% CI: 0.34–0.80 (P < 0.001 for trend). A significant decrease in RBP4 after follow-up was also noted in participants with NAFLD regression.

Conclusion. – Serum RBP4 concentrations are associated with the development and regression of NAFLD, making them a potential novel preventative and therapeutic target in NAFLD management.

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Keywords : Adipokine, Fatty liver disease, Longitudinal study



© 2019  Publié par Elsevier Masson SAS.
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