Drug survival of secukinumab and ixekizumab for moderate-to-severe plaque psoriasis - 16/05/19

Doi : 10.1016/j.jaad.2019.03.048

Alexander Egeberg, MD, PhD ^a,^⁎ , Lars Erik Bryld, MD, PhD ^b, Lone Skov, MD, PhD, DMSc ^a
^a Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, Hellerup, Denmark
^b Department of Dermatology, Zealand University Hospital, University of Copenhagen, Roskilde, Denmark

^∗Correspondence to: Alexander Egeberg, MD, PhD, Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, 2900 Hellerup, Denmark.Department of Dermatology and AllergyHerlev and Gentofte HospitalUniversity of CopenhagenHellerup2900Denmark

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Abstract

Background

Biologics targeting interleukin 17 are increasingly being used for treatment of moderate-to-severe psoriasis, but data on drug survival for these therapies remain scarce.

Objectives

To investigate the drug survival of secukinumab and ixekizumab in a nationwide cohort of patients with psoriasis in Denmark.

Methods

Using DERMBIO, we examined Danish patients receiving treatment with secukinumab or ixekizumab according to the standard in-label dosing. Kaplan-Meier plots were used to present survival curves.

Results

In all, 368 and 62 patients received treatment with secukinumab and ixekizumab, respectively. In total, 40.7% and 12.9% of secukinumab- and ixekizumab-treated patients were bionaive. Ixekizumab-treated patients had received significantly more previous treatments. Over 12 months, 23.5% and 0.0% of bionaive secukinumab- and ixekizumab-treated patients discontinued therapy, respectively. Drug survival for bionaive and non-naive patients was lower for secukinumab than for ixekizumab. During the maximum 3 years of follow-up, secukinumab drug survival was lowest for patients who had previously been treated with 2 or more biologics, followed by patients treated with secukinumab as their second-ever biologic.

Limitations

The total number of patients and follow-up time were modest.

Conclusions

Drug survival was higher for ixekizumab even though secukinumab-treated patients had been treated with significantly fewer biologics before starting this drug.

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Key words : biologics, drug survival, IL-17, ixekizumab, psoriasis, secukinumab

Abbreviations used : IL, SD

Plan

Materials and methods

Data sources and study population

	Funding sources: None.
	Disclosure: Dr Egeberg has received research funding from Pfizer, Eli Lilly and Company, the Danish National Psoriasis Foundation, and the Kgl Hofbundtmager Aage Bang Foundation and honoraria as a consultant and/or speaker from AbbVie, Almirall, Leo Pharma, Samsung Bioepis Co, Ltd, Pfizer, Eli Lilly and company, Novartis, Galderma, and Janssen Pharmaceuticals. Dr Skov has been a paid speaker for Pfizer, AbbVie, Eli Lilly and Company, Novartis, and LEO Pharma and has been a consultant or served on advisory boards with Pfizer, AbbVie, Janssen Cilag, Novartis, Eli Lilly and Company, LEO Pharma, and Sanofi. She has served as an investigator for Pfizer, AbbVie, Eli Lilly and Company, Novartis, Amgen, Regeneron, and LEO Pharma and received research and educational grants from Pfizer, AbbVie, Novartis, Sanofi, Janssen Cilag, and Leo Pharma. The authors do not have equity in pharmaceutical companies.
	Dr Egeberg had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis, as well as for the study concept, design and drafting of the article, and statistical analysis. Drs Egeberg, Bryld, and Skov all take responsibility for acquisition, analysis, and interpretation of the data, as well as for critical revision of the article for important intellectual content. Drs Egeberg and Skov take responsibility for administrative, technical, or material support, as well as for study supervision.
	Reprints not available from the authors.