CEMIP promotes ovarian cancer development and progression via the PI3K/AKT signaling pathway - 17/05/19
, Zhi-hong Zong b , Yao Liu c , Shuo Chen a , Xiu-jie Sheng a, ⁎ , Yang Zhao a, ⁎ Bienvenue sur EM-consulte, la référence des professionnels de santé.
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Highlights |
• | CEMIP knockdown reduces proliferation and increases apoptosis of ovarian cancer cells. |
• | CEMIP knockdown significantly reduces migration and invasion capacity of ovarian cancer cells. |
• | CEMIP silencing inhibits activation of the PI3K/AKT signaling pathway. |
• | CEMIP may promote development of ovarian cancer via activation of PI3K/AKT signaling. |
Abstract |
CEMIP is a cell migration-inducing protein that is closely associated with carcinogenesis. However, the function of CEMIP has not been reported in ovarian cancer. Here we show that CEMIP expression level in ovarian cancer tissues was higher than that in normal ovaries. Silencing of CEMIP in ovarian cancer cell lines A2780 and OVCAR3 significantly decreased cell proliferation, cell migration and invasion capacity, while the proportion of apoptotic cells was increased. In addition, Western blotting demonstrated that knockdown of CEMIP inhibited activation of the PI3K/AKT signaling pathway. Altogether, these data suggest that CEMIP may promote the development of ovarian cancer by regulating PI3K/AKT signaling.
Le texte complet de cet article est disponible en PDF.Keywords : CEMIP, Ovarian cancer, Tumorigenesis, Metastasis, PI3K/AKT signaling
Plan
Vol 114
Article 108787- juin 2019 Retour au numéro
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