The effect and mechanisms of Fuzheng Huayu formula against chronic liver diseases - 17/05/19

Doi : 10.1016/j.biopha.2019.108846

Jiamei Chen ^a,^b,^{^{1
These authors contributed equally to this study.}}, Yonghong Hu ^a,^b,^{^{1
These authors contributed equally to this study.}}, Long Chen ^a,^b, Wei Liu ^a,^b, Yongping Mu ^a,^b, Ping Liu ^a,^b,^c,^⁎
^a Institute of Liver Diseases, Key Laboratory of Liver and Kidney Diseases (Ministry of Education), Shuguang Hospital affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China
^b Shanghai Key Laboratory of Traditional Chinese Medicine, Shanghai, 201203, China
^c E-Institute of Shanghai Municipal Education Commission Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China

^⁎Corresponding author at: Institute of Liver Diseases, Key Laboratory of Liver and Kidney Diseases (Ministry of Education), Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.Institute of Liver DiseasesKey Laboratory of Liver and Kidney Diseases (Ministry of Education)Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai201203China

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Abstract

Fuzheng Huayu formula (FZHY) is a traditional Chinese medicine formula composed of Radix Salvia Miltiorrhizae, Cordyceps, Semen Persicae, Gynostemma Pentaphyllammak, Pollen Pini, Fructus Schisandrae Chinensis that is used to treat chronic liver diseases in China. We here describe the pharmacological actions of FZHY in this review. We also describe and provide updates on recent advances in the medical applications and the basic research of mechanisms of FZHY formula. FZHY has been shown to have no serious adverse reactions and exerts antifibrotic effects through targeting more than one molecule.

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Abbreviations : FZHY, HCC, HPLC/ESI-MS, DSS, ROS, SAB, AUC, IFN-γ, DMN, NASH, PBC, ALT, AST, TG, TC, LDL, HDL, PPC, HA, PC III, LN, C IV, α-SMA, Col I, ECM, CCl₄, TGF-β1, UDCA, MMPs, TIMP-2, TNF- α, IL-6, LSEC, vWF, HBV, TCM, HSC, hESCs

Keywords : Fuzheng Huayu, Chronic liver disease, Clinical application, Antifibrotic effect, Mechanism

Plan

Introduction

Bioactive components, pharmacokinetics, and tissue distribution profiles after oral administration of Fuzheng Huayu formula

Clinical effects of Fuzheng Huayu formula on chronic liver diseases

Treatment of non-alcoholic steatohepatitis

Treatment of primary biliary cirrhosis

Treatment of chronic hepatitis B and HBV-related fibrosis/cirrhosis

Treatment of esophageal variceal bleeding

Treatment of HCV-related fibrosis/cirrhosis

Mechanisms underlying action of Fuzheng Huayu formula in the treatment of chronic liver disease

Inhibition of hepatic stellate cell activation

Inhibition of inflammatory response

Regulation of extracellular matrix deposition

Protection of hepatocytes from damage and apoptosis

Inhibition of hepatic sinusoid capillarization and angiogenesis

Promotion of liver regeneration

Conclusions

Author contributions

Conflict-of-interest statement

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Vol 114

Article 108846- juin 2019 Retour au numéro

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The effect and mechanisms of Fuzheng Huayu formula against chronic liver diseases - 17/05/19

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