Prevalence estimates for chronic urticaria in the United States: A sex- and age-adjusted population analysis - 21/05/19

Doi : 10.1016/j.jaad.2019.02.064

Sara Wertenteil, BA, Andrew Strunk, MA, Amit Garg, MD ^⁎
Department of Dermatology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New Hyde Park, New York

^∗Correspondence to: Amit Garg, MD, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, 1991 Marcus Ave, Ste 300, New Hyde Park, NY, 11042.Donald and Barbara Zucker School of Medicine at Hofstra/Northwell1991 Marcus Ave, Ste 300New Hyde ParkNY11042

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Abstract

Background

Disease burden in chronic urticaria (CU) is poorly understood.

Objective

To estimate standardized overall and sex-, age-, and race-specific prevalence estimates for CU among adults in the United States.

Methods

A cross-sectional analysis with electronic health records data for a demographically heterogeneous population-based sample of >55 million patients across all 4 census regions.

Results

The overall CU prevalence was 0.23%, or 230 CU cases/100,000 adults. The adjusted prevalence in women was 310 (95% confidence interval [CI] 307-312) cases/100,000 adults, more than twice that of men (146 [95% CI 143-148] cases/100,000 adults, P < .001). CU prevalence was highest among patients aged 40-49 years (256 [95% CI 252-261] cases/100,000 adults) and 50-59 years (246 [95% CI 242-251] cases/100,000 adults) compared with all other age groups (P < .0001). Adjusted prevalences for black (292 [95% CI 285-298] cases/100,000 adults) and other (331 [95% CI 323-338] cases/100,000 adults) patients were higher than that for white patients (262 [95% CI 260-264] cases/100,000 adults; P < .001).

Limitations

Use of administrative data has the potential to underestimate burden.

Conclusion

There are >500,000 people estimated to have CU in the United States, most of whom are women or adults ≥40 years of age.

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Key words : burden of disease, chronic urticaria, Explorys, population-based, prevalence, urticaria

Abbreviations used : CI, CU, ICD, SNOMED-CT

Plan

	Funding sources: None.
	Conflicts of interest: Dr Garg has served as an advisor for AbbVie, Pfizer, Janssen, and Asana Biosciences and received honoraria. Ms Wertenteil and Mr Strunk have no conflicts of interest to disclose.
	Reprints not available from the authors.