Radiological assessment of mandibular invasion in squamous cell carcinoma of the oral cavity and oropharynx - 11/06/19

Doi : 10.1016/j.anorl.2019.05.005

S. Bouhir ^a, G. Mortuaire ^a, F. Dubrulle-Berthelot ^b, X. Leroy ^c, V. Deken-Delannoy ^d, B. Rysman ^a, D. Chevalier ^a, F. Mouawad ^a,^e,^⁎
^a Service d’ORL et de chirurgie cervico-faciale, CHU de Lille, université de Lille, hôpital Huriez, rue Michel-Polonovski, 59037 Lille, France
^b Service de radiologie et imagerie interventionnelle, CHU de Lille, université de Lille, hôpital Huriez, rue Michel-Polonovski, 59037 Lille, France
^c Service d’anatomo-pathologie, centre de biologie pathologie, CHU de Lille, université de Lille, boulevard du Professeur Jules-Leclercq, 59037 Lille, France
^d Unité de méthodologie, biostatistique et data management, maison régionale de la recherche clinique, CHU de Lille, rue du Professeur Laguesse, 59037 Lille, France
^e Inserm U 908, UFR de biologie, SN3, université des sciences et technologies de Lille, 59655 Villeneuve d’Ascq, France

^⁎Corresponding author. 1, boulevard de Verdun, Lille, France.1, boulevard de VerdunLilleFrance

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Abstract

Background

Preoperative assessment of mandibular bone invasion in squamous cell carcinoma of the oral cavity and oropharynx is crucial for optimizing bone resection. The principal aim of this study was to evaluate the diagnostic value of CT and MR imaging for the diagnosis of mandibular bone invasion compared to the histological reference. In addition, we assessed the survival impact of bone invasion.

Patients and methods

A single-center retrospective study included all consecutive patients treated by mandibular bone interruption for squamous cell carcinoma of the oral cavity and/or oropharynx.

Results

Sixty-eight patients were included. Prevalence of bone invasion on histology was 43%. Sensitivity, specificity and positive and negative predictive value were respectively 70%, 71%, 66% and 76% for CT compared with histologic analysis, 83%, 50%, 59% and 78% for MRI, and 83%, 62% 62%, 83% for associated CT and MRI. The two tests showed good agreement, with kappa index 0.69 (95% CI, 0.49–0.89) (P<0.0001). There was no difference in overall survival (log-rank>0.70) between the groups with and without bone invasion.

Conclusion

CT and MRI are complementary for preoperative assessment of mandibular bone invasion, be it cortical and/or medullary, and in some cases may allow mandibular bone-sparing.

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Keywords : Mandibular bone invasion, Oropharyngeal and oral cavity cancer, Computed tomography, Magnetic resonance imaging, Sensitivity and specificity