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Previous studies have found familial aggregation of melanoma and keratinocyte cancers (KCs).
We sought to determine the risk of melanoma and KCs in those with a positive family history of melanoma while controlling for pigmentary and environmental risk factors.
We prospectively followed 216,115 participants from the Nurses' Health Study, Nurse's Health Study 2, and Health Professionals Follow-up Study for more than 20 years. Cox proportional hazards regression controlling for known risk factors for skin cancer was used to estimate association between family history of melanoma and melanoma and KCs.
Compared with those without a family history of melanoma, individuals with a family history of melanoma had a 74% increased risk of melanoma (hazard ratio [HR], 1.74; 95% confidence interval [CI], 1.45-2.09), a 22% increased risk of squamous cell carcinoma (HR, 1.22; 95% CI, 1.06-1.40), and a 27% increased risk of basal cell carcinoma (HR, 1.27; 95% CI, 1.12-1.44). Family history of melanoma increased the risk of development of truncal melanoma in both sexes, extremity melanoma in women, and extremity squamous cell carcinoma in women.
Limitations of this study include self-reported family history and detection bias.
Individuals with a family history of melanoma are at an increased risk of melanoma and KCs.Le texte complet de cet article est disponible en PDF.
Key words : basal cell carcinoma, family history of melanoma, keratinocyte cancers, melanoma, prospective cohort studies, risk factor, skin cancer, squamous cell carcinoma
Abbreviations used : BCC, BMI, CI, HPFS, KC, NHS, NHS2, SCC, UV, UVR
| Dr Wei and Dr Li contributed equally to this article.
| Funding sources: Supported in part by the National Institutes of Health (grants UM1 CA186107, P01 CA87969, UM1 CA176726, UM1 CA167552, and R01 CA137365). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. The funding source had no role in the design of the study, data collection, analysis, interpretation of the data, manuscript writing, or decision to submit the manuscript for publication.
| Conflicts of interest: None disclose.
| The authors had full access to all of the data in the study and take responsibility for the integrity of the data and accuracy of the data analysis.