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There are multiple, genetically distinct pathways that give rise to melanoma. Melanomas on sun-damaged skin (MSDS), including lentigo maligna and desmoplastic melanoma, have distinct genetic profiles and are uniquely linked to chronic ultraviolet exposure. In this article, we discuss the etiologies of lentigo maligna and desmoplastic melanoma, emerging diagnostic adjuncts that might be helpful for accurately identifying these lesions, and the clinical relevance of their frequent co-occurrence. We present unique and overlapping features of these entities and discuss challenges in MSDS management, including margin assessment, excision, and the potential role of nonsurgical therapy. Last, we address the role of immunotherapy in invasive disease. Understanding MSDS as distinct from melanoma arising on intermittently sun-exposed or sun-protected skin will ultimately help optimize patient outcomes.Le texte complet de cet article est disponible en PDF.
Key words : dermoscopy, desmoplastic melanoma, lentigo maligna melanoma, melanoma, reflectance confocal microscopy, sun-damaged skin
Abbreviations used : AAD, DM, LM, LMM, MIS, MMS, MSDS, NCCN, RCM, UV, UVR
| Funding sources: None.
| Conflicts of interest: Dr Rabinovitz and Msd Oliviero have received honoraria in the past from Caliber, a company that produces reflectance confocal microscopes. Dr Grant-Kels and Dr Rabinovitz have also received equipment in the past from Caliber. There were no payments for conducting or publishing this study. Ms DeWane and Dr Kelsey have no conflicts of interest to disclose.