Random sampling in the air and from environmental items in operating rooms without laminar airflow were performed during our first PIPAC procedures.
Only one sample out of 31 was moderately contaminated with cisplatin.
PIPAC performed in operating rooms without laminar airflow might seem harmless for surgeons and their co-workers.
Aim of the study
The safety of pressurized intraperitoneal aerosol chemotherapy (PIPAC) is often questioned when newly implemented in an operating room (OR); as it may increase the risk of exposure to cytotoxics for healthcare workers. There are no data on the risk of healthcare exposure in OR without laminar airflow. We aimed to ensure the safety of PIPAC for surgeons and their co-workers for newly implemented procedures in an OR without laminar airflow.
Patients and methods
Twenty-six samples with cellulosic wipes from surgeons and co-workers’ environmental items and 5 specific polytetrafluoroethylene air-filtered collections were randomly performed for the first 2 cisplatin/doxorubicin-based PIPAC procedures in Strasbourg University Hospital. PIPAC was performed according to previously described safety protocol but without a laminar airflow and with an additional plastic cover and smoke evacuation device. Sampling and analyzes were performed by 2 accredited independent certified organizations.
All air measurements were negative for cisplatin and doxorubicin. Only one wipe sample out of 26 was positive for cisplatin (4%) on the outer surgeon's pair of gloves but dosages on the surgeon's inner pair and hands were negative.
When performed in approved security conditions, even without laminar airflow, PIPAC might seem harmless for surgeons and their co-workers with very limited risk of exposure to cytotoxics.Le texte complet de cet article est disponible en PDF.
Keywords : PIPAC, Occupational safety, Samplings, Laminar airflow
|☆|| This study had been presented as a poster presentation at the PSOGI 2018 congress, Paris, September 9-11, 2018. The abstract is published in Pleura and Peritoneum 2018;1, Special Suppl, September 2018.