Coffee, tea, caffeine, and risk of nonmelanoma skin cancer in a Chinese population: The Singapore Chinese Health Study - 27/07/19
Abstract |
Background |
Although epidemiologic studies in populations of European descent suggest a possible chemoprotective effect of caffeine against nonmelanoma skin cancer (NMSC), data in Asian populations are lacking.
Objectives |
We examined the relationship of coffee, tea, and caffeine consumption with NMSC risk among Chinese in Singapore.
Methods |
We used data from the Singapore Chinese Health Study, a prospective cohort of 63,257 men and women who were 45 to 74 years old at recruitment from 1993 to 1998. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated by using multivariable Cox proportional hazard models.
Results |
Coffee drinking was associated with reduced NMSC risk in a dose-dependent manner (P trend < .0001). Compared with those who drank coffee less than weekly, those who drank 3 or more cups per day had a lower risk of basal cell carcinoma (HR, 0.54; 95% CI, 0.31-0.93) and a lower risk of squamous cell carcinoma (HR, 0.33; 95% CI, 0.13-0.84). Compared with nondrinkers of black tea, daily drinkers of black tea also had a reduced risk of NMSC (HR, 0.70; 95% CI, 0.52-0.94). Caffeine intake reduced NMSC risk in a stepwise manner (P trend = .0025); subjects with a caffeine intake of 400 mg/d or more had the lowest risk (HR, 0.59; 95% CI, 0.34-1.04).
Conclusion |
Consumption of caffeinated drinks such as coffee and black tea may reduce the risk of NMSC among Chinese.
Le texte complet de cet article est disponible en PDF.Key words : caffeine, Chinese, coffee, nonmelanoma skin cancer, tea
Plan
Funding sources: Supported by the National Institutes of Health (grants R01 CA144034 and UM1 CA182876). Dr Koh is supported by the National Medical Research Council, Singapore (grant NMRC/CSA/0055/2013). |
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Conflicts of interest: None disclosed. |
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Reprints not available from the authors. |
Vol 81 - N° 2
P. 395-402 - août 2019 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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