Wedelolactone alleviates doxorubicin-induced inflammation and oxidative stress damage of podocytes by I?K/I?B/NF-?B pathway - 31/07/19
, Liang Feng a, ⁎ Bienvenue sur EM-consulte, la référence des professionnels de santé.
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Graphical abstract |
Highlights |
• | Wedelolactone, a natural compound, shows outstanding effects of anti-inflammation and anti-oxidative stress. |
• | The alleviation to doxorubicin(DOX)-driven podocyte injury may contribute to the attenuation of renal damage. |
• | Wedelolactone can regulate the IκK/IκB/NF-κB signaling pathway to alleviate levels of oxidative stress and inflammation. |
Abstract |
The acute kidney injury(AKI) caused by nephrotoxic drugs contributes to inflammation and oxidative injury in podocytes. Wedelolactone (WED), a natural compound, is found with activities as anti-inflammation, anti-oxidative, anti-free radical,and etc. In this present study, MPC-5 cells were exposed to the nephrotoxic drugs doxorubicin (DOX). The results showed that WED significantly increased the SOD activity, CAT and GSH-Px levels, while significantly decreased the MDA content and ROS levels in DOX-induced MPC-5 cells. WED could also significantly decrease the levels of cytokines IL-6, MCP-1, TNF-α, and TGF-β1. Additionally, the activation and phosphorylation of IκKα, IκBα and NF-κB p65 was inhibited by WED. The co-treatment of PDTC (NF-κB inhibitor) and WED significantly reduced NF-κB p65 phosphorylation. These findings suggested that WED alleviated inflammation and oxidative stress of doxorubicin-induced MPC-5 cells through IκK/IκB/NF-κB signaling pathway.
Le texte complet de cet article est disponible en PDF.Keywords : Wedelolactone, Doxorubicin, Podocyte, Inflammation, Oxidative stress
Plan
Vol 117
Article 109088- septembre 2019 Retour au numéro
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