Pinosylvin reduced migration and invasion of oral cancer carcinoma by regulating matrix metalloproteinase-2 expression and extracellular signal-regulated kinase pathway - 31/07/19
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
| pages | 9 |
| Iconographies | 7 |
| Vidéos | 0 |
| Autres | 0 |
Highlights |
• | Pinosylvin restrained the migration and invasion of oral cancer cells. |
• | Pinosylvin reduced the enzyme activity of MMP-2 and increased the TIMP-2 expression in oral cancer cells. |
• | Pinosylvin inhibited the ERK pathway in human oral cancer cells. |
• | ERK signaling pathway in pinosylvin-mediated suppression of OSCC cells. |
Graphical abstract |
Abstract |
Background |
Pinosylvin possesses several biological properties, including anti-inflammatory, antitumor, and antioxidant characteristics. However, the effects of pinosylvin on the migration and invasion of human oral cancer cells and the underlying mechanisms remain unclear.
Hypothesis/purpose |
In this research, we investigated the outcome of different concentrations of pinosylvin (0–80 μM) on the metastatic and invasive abilities of SAS, SCC-9, and HSC-3 cells.
Methods and results |
Western blotting assay and Gelatin zymography assay indicated that pinosylvin inhibited the enzymatic activity of matrix metalloproteinase-2 (MMP-2) and reduced its protein level but increased the expression of tissue inhibitor of metalloproteinase-2 (TIMP-2). Additionally, the wound healing assay and Transwell method showed that pinosylvin reduced the migration of SAS, SCC-9 and HSC-3 oral cancer cells. Besides, pinosylvin decreased the phosphorylation of ERK1/2 protein experssion in both SAS and SCC-9 cells.
Conclusion |
These results indicate that pinosylvin is a potential anticancer agent for preventing oral cancer metastasis.
Le texte complet de cet article est disponible en PDF.Abbreviations : OSCC, ECM, TIMPs, ERKs, JNKs, MAPK
Keywords : Oral squamous cell carcinoma, Pinosylvin, MMP-2, TIMP-2, Migration
Plan
Vol 117
Article 109160- septembre 2019 Retour au numéro
Article précédent
- Low dose of chronic ethanol exposure in adult zebrafish induces hepatic steatosis and injury
- Ki-Hoon Park, Seok-Hyung Kim
- Protective effect of Ziziphora clinopodioides flavonoids against H2O2-induced oxidative stress in HUVEC cells
- Yuche Wu, Yanming Wang, Xinhua Nabi
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’achat d’article à l’unité est indisponible à l’heure actuelle.
Déjà abonné à cette revue ?