Expression and clinical significance of CPS1 in glioblastoma multiforme - 05/09/19

Doi : 10.1016/j.retram.2019.08.003

Geting Wu ^a,^{^{1
These authors provided equal contribution to this work.}}, Yuanliang Yan ^b,^c,^{^{1
These authors provided equal contribution to this work.}}, Yangying Zhou ^d, Xiang Wang ^b,^c, Jie Wei ^b,^c, Xi Chen ^b,^c, Wei Lin ^a, Chunlin Ou ^a, Jianhua Zhou ^a,⁎ , Zhijie Xu ^a,⁎
^a Department of Pathology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China
^b Department of Pharmacy, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China
^c National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China
^d Department of Oncology, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China

^⁎Corresponding authors.

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Abstract

Carbamoyl phosphate synthetase-1 (CPS1), the first rate-limiting mitochondrial enzyme in the urea cycle, regulates proliferation and differentiation during tumor progression. However, the detailed function of CPS1 in glioblastoma Multiforme (GBM) is still unclear. Here, we highlight mechanisms for CPS1 upregulation and the effects of upregulated CPS1 on GBM tumorigenesis. The transcriptome data from several public databases, such as Oncomine and GEPIA, revealed that CPS1 transcriptional level was significantly upregulated in GBM tissues and cells. Moreover, CPS1 was hypomethylated in GBM tissues. The Wanderer database, linked to the Cancer Genome Atlas (TCGA), showed the association between CPS1 expression or its methylation values and the clinicopathological parameters in GBM patients. Our work fully demonstrated that CPS1 expression was upregulated in GBM and this gene could be used as a potential diagnostic and prognosis indicator for GBM.

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Keywords : CPS1, Glioblastoma multiforme, TCGA, Diagnosis