Meta-analysis of the association between MBOAT7 rs641738, TM6SF2 rs58542926 and nonalcoholic fatty liver disease susceptibility - 29/09/19
, Mei-Hua Bao a, c, e, ⁎ Bienvenue sur EM-consulte, la référence des professionnels de santé.
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Highlights |
• | 5415 cases and 17896 controls were included in the present meta-analysis. |
• | Patients with CC genotype of TM6SF2 rs58542926 were with lower risk of NAFLD. |
• | No association existed between MBOAT7 rs641738 and NAFLD risks. |
• | TM6SF2 rs58542926 might be a biomarker for NAFLD risks. |
Summary |
Background |
Nonalcoholic fatty liver disease (NAFLD) is a kind of liver disease caused by factors other than excessive alcohol use. It is the leading cause of liver injury in developed countries. The membrane-bound O-acyltransferase 7 (MBOAT7) and transmembrane 6 superfamily member 2 (TM6SF2) are associated with lipid metabolism. Studies found a mutation on MBOAT7, rs641738 and another on TM6SF2, rs58542926 were associated with liver diseases, including NAFLD. However, the results were inconclusive and inconsistent.
Methods |
In the present meta-analysis, the databases Pubmed, Embase, Chinese National Knowledge Infrastructure, and Chinse Biomedical Literature Database were searched for related studies. The deadline of publications was July 10th, 2018. The data from included studies were extracted by 2 independent investigators. STATA 12.0 software was used in the present meta-analysis.
Results |
A total of 9 papers with 20 studies, including 5415 cases and 17896 controls were identified for the meta-analysis. The results indicated lower risks of NAFLD for CC genotype of TM6SF2 rs58542926 in homozygous, heterozygous, dominant and recessive models (CC vs. TT: OR = 0.33; CC vs. CT: OR = 0.58; CC vs. CT + TT: OR = 0.64; CC + CT vs. TT: OR = 0.32). These decreased risks of NAFLD also existed in Asians in all genetic models except allelic model, and in Caucasians in the heterozygous model (CC vs. CT, OR = 0.52) and the dominant model (CC + CT vs. TT, OR = 0.50). No association existed between MBOAT7 rs641738 and NAFLD risks in all genetic models (CC vs. TT: OR = 0.91; CC vs. CT: OR = 0.96; CC vs. CT + TT: OR = 0.95; CC + CT vs. TT: OR = 0.91; C vs. T: OR = 0.99).
Conclusion |
CC genotype of TM6SF2 rs58542926 was associated with a significantly lower risk of NAFLD, while MBOAT7 rs641738 was not related to NAFLD risks.
Le texte complet de cet article est disponible en PDF.Keywords : Nonalcoholic fatty liver disease, membrane-bound O-acyltransferase 7, transmembrane 6 superfamily member 2, rs58542926, rs641738, meta-analysis
Plan
Vol 43 - N° 5
P. 533-541 - octobre 2019 Retour au numéro
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