Unclassified hepatocellular adenoma expressing ASS1 associated with inflammatory hepatocellular adenomas - 29/09/19
Highlights |
• | Drafting the work or revising it critically for important intellectual content CB, PBS. |
• | Final approval of the version to be published: all authors. |
• | Agreement to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved: all authors. |
Summary |
Three liver nodules were fortuitously discovered in a 30-year-old obese woman during a gynecological workup and resected. Two nodules (6 and 1.5 cm) with histological characteristics of inflammatory hepatocellular adenoma (HCA) were C reactive protein positive with normal expression of glutamine synthetase. The third 6 cm nodule had all the characteristics of an Unclassified HCA with an overexpression of Argininosuccinate Synthase 1 (ASS1) in the tumor compared to the non-tumoral liver. The non-tumoral liver was highly steatotic. Upon MRI review, two HCAs were identified as inflammatory HCAs based on specific criteria. The third HCA was different from the other two with the presence of peculiar intratumoral fluid cavities. This first report on the association between unclassified HCA expressing ASS1 and inflammatory HCA reinforces the concept that common factors are implicated in HCA subtypes genesis. ASS1 is an interesting immuno-marker to identify among unclassified HCA a subgroup with a high risk of bleeding. ASS1 overexpression decreases sharply the number of “true” unclassified HCA.
Le texte complet de cet article est disponible en PDF.Keywords : Hepatocellular adenoma, ASS1+ hepatocellular adenoma, Inflammatory hepatocellular adenoma
Plan
Vol 43 - N° 5
P. e63-e67 - octobre 2019 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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