Objective of this paper is to present a reliable and accurate technique for Myocardial Infarction (MI) detection and localization.

Stationary wavelet transform has been used to decompose the ECG signal. Energy, entropy and slope based features were extracted at specific wavelet bands from selected lead of ECG. k-Nearest Neighbors (kNN) with Mahalanobis distance function has been used for classification. Sensitivity (Se), specificity (Sp), positive predictivity (+P), accuracy (Acc), and area under the receiver operating characteristics curve (AUC) analyzed over 200 subjects (52 health control, 148 with MI) from Physikalisch-Technische Bundesanstalt (PTB) database has been used for performance analysis. To handle the imbalanced data adaptive synthetic (ADASYN) sampling approach has been adopted.

For detection of MI, the proposed technique has shown an AUC = 0.99, Se = 98.62%, Sp = 99.40%, PPR = 99.41% and Acc = 99.00% using 12 top ranked features, extracted from multiple leads of ECG and AUC = 0.99, Se = 98.34%, Sp = 99.77%, PPR = 99.77% and Acc = 99.05% using 12 features extracted from a single ECG lead (i.e. lead V5). For localization of MI, the proposed technique has an AUC = 0.99, Se = 98.78%, Sp = 99.86%, PPR = 98.80%, and Acc = 99.76% using 5 top ranked features from multiple leads of ECG and AUC = 0.98, Se = 96.47%, Sp = 99.60%, PPR = 96.49% and Acc = 99.28% using 8 features extracted from a single ECG lead (i.e. lead V3).

Thus for MI detection and localization, the proposed technique is independent of time-domain ECG fiducial markers and can work using specific leads of ECG.