The influence of fetal gender and maternal characteristics on fetal cell-free DNA in maternal plasma - 06/10/19
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Abstract |
Objective |
To examine the possible effects of fetal gender and maternal characteristics on concentration of fetal cell-free DNA (cfDNA).
Methods |
Maternal plasma that collected from 2638 singleton pregnancies women were analyzed using non-invasive prenatal testing for aneuploidy by next generation sequence technology. The effects of fetal gender and maternal BMI on fetal cfDNA was measured by Pearson correlation analysis.
Results |
The proportion of fetal cfDNA was positively correlated with gestational age (regression equation: Y=16.2483+6.8856X, r=0.1660, p<0.0001); and negatively correlated with BMI (Body Mass Index) (regression equation: Y=25.6342–19.0065X, r=−0.2146, p<0.0001); Concentration of female fetal cfDNA (mean fetal cfDNA is 13.07%, p<0.0001) is higher than male fetal cfDNA (mean fetal cfDNA is 8.37%, p<0.0001).
Conclusions |
Fetal cfDNA increases stably between 12 and 20 weeks of gestation, and increases in a higher rate after 20 weeks. The maternal BMI is an important factor affecting fetal cfDNA, should be paid enough attention in clinical application.
Le texte complet de cet article est disponible en PDF.Keywords : Cell-free DNA, Fetal gender, Gestational age, Body mass index, Non-invasive prenatal testing
Plan
Vol 48 - N° 8
P. 653-656 - octobre 2019 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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