Exposure to TNF antagonist therapies induces variations of the gut microbiota in an in vivo model using healthy mice - 12/10/19
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Highlights |
• | There is currently no study on the impact of biologic therapeutics on the microbiome, despite variable patients’ response to biologics used to treat gut-joint-axis diseases. |
• | We studied microbiome variations resulting from different TNF-antagonist treatments in an in vivo mouse model. |
• | We showed a dysbiosis of the microbiome after treatment in young mice, and identified major bacteria involved in TNF-antagonists exposure. These bacteria were different between males and females. |
Keywords : Gut microbiome, TNF inhibitors, Dysbiosis
Plan
☆ | Disclaimer: This manuscript reflects the views of the authors and should not be construed to represent FDA's views or policies. |
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