Prebiotic, immuno-stimulating and gut microbiota-modulating effects of Lycium barbarum polysaccharide - 30/11/19
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Graphical abstract |
Highlights |
• | Lycium barbarumpolysaccharide (LBP) has prebiotic properties and enhanced the growth of probiotic bacteria (L. acidophilus and B. longum) in vitro. |
• | LBP could modulate the composition and enriched the beneficial species of gut microbiota. |
• | LBP could enhance the host innate immune response and can increase the level of TGF-β and IL-6 in serum and sIgA in the colon. |
• | LBP represents an attractive source of prebiotic nutraceuticals for the food and pharmaceutical industry. |
Abstract |
The present study was done to evaluate the prebiotic effect of Lycium barbarum polysaccharide (LBP), its effect on murine fecal microbiota composition and innate immune response. Results showed that LBP supports the growth of selective probiotic bacteria with a maximum of 8.23 (log10 cfu/mL) and 6.62 (log10 cfu/mL) for Lactobacillus acidophilus and Bifidobacterium longum respectively. In vivo studies revealed that the administrations of LBP to mice resulted in an increase in the abundance of the phyla Proteobacteria and Firmicutes, while reducing the ratio of the phylum Bacteroidetes. At the genus level, the administration of LBP stimulated the emergence of some potential probiotic genera (Akkermansia, Lactobacillus, and Prevotellaceae). The concentrations of TGF-β and IL-6 in serum and sIgA in the colon content were enriched significantly after LBP administrations in mice. The thymus index and spleen index of mice treated with LBP displayed significant difference compared to the control group (P < 0.05). These findings suggest that LBP is a good source as a potential prebiotic and can enhance the intestinal microbiota and boost beneficial bacteria levels, modulate innate immune response.
Le texte complet de cet article est disponible en PDF.Keywords : Lycium barbarum polysaccharide, Prebiotic activity, Innate immune, Intestinal microbiota
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Vol 121
Article 109591- janvier 2020 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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