Twenty years ago, new psychoactive substances (NPS) emerged in France and their number has substantially increased during the 2010s. Identification of these compounds and their isomers, however, is complex. We report a case of seizure of 41 powders at the home of a man who consumed various drugs for recreational purposes and to regulate his sleep cycle. Thirty-three different compounds were identified using nuclear magnetic resonance (NMR) spectroscopy and gas chromatography coupled to a quadruple mass spectrometer or a time-of-flight mass spectrometer. Two of these were classic drugs (cocaine and MDMA), 1 was an alkaloid present in plants (mesembrine), 1 was a diverted drug (methylphenidate) and 29 were NPSs. Two NPS were reported for the first time in France: 3C-P and dichloropane. The dichloropane was identified by analyzing its structure using Molecular Structure Correlator software, confirmed by NMR analysis.