Clinical factors predictive for histological aggressiveness of basal cell carcinoma: A prospective study of 2274 cases - 10/12/19
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Abstract |
Introduction |
Since surgery is the first-line treatment for basal cell carcinomas (BCC), the histological aggressiveness of the disease must be clinically predicted in order to apply optimal safety margins that ensure a high rate of complete resection while minimising the risk of recurrence.
Objectives |
To evaluate clinical predictive factors of histological aggressiveness of BCC, we conducted a national prospective multi-centre study.
Methods |
All consecutive patients presenting for BCC surgery were included, and standardised clinical data collected, and slides were submitted for review. Trabecular, micronodular and morpheaform BCCs were classified as aggressive.
Results |
Of the 2710 cases included, 2274 were histologically confirmed. Clinical subtyping was correct in 49.9% of superficial BCCs, 86.2% of nodular BCCs and only 22% of aggressive BCCs. By multivariate analysis, aggressive BCCs were more frequently ulcerated (45%), indurated (70%), showed adherence (8.6%), and were associated with high-risk anatomical zones (50.3%, P<0.0001). These predictive clinical features may be helpful for decision making.
Le texte complet de cet article est disponible en PDF.Keywords : Basal cell carcinoma, Dermatological surgery, Histological subtype, Skin cancer, Dermatopathology
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