Prediction of the development of carbohydrate disorders in patients with arterial hypertension based on an assessment of the levels of interleukin-10 and glycosylated haemoglobin - 06/01/20
Résumé |
The purpose of study was to develop a diagnostic algorithm for prediction of type 2 diabetes mellitus (T2DM) based on a comprehensive study of carbohydrate metabolism and serum activity of interleukin-10 (IL-10) in patients with arterial hypertension (AH).
Methods |
The study involved 69 patients with AH. The levels of fasting plasma glucose (FPG, mmol/L), insulin, HbA1c (%) were determined by biochemical method, HOMA index was calculated. The level of IL-10 (pg/mL) was determined by ELISA. A discriminant analysis was used to identify the dependencies that explain the mechanisms of T2DM development in patients with AH.
Results |
As the result of evaluation of carbohydrate metabolism, 30 patients were diagnosed with T2DM (FPG>7.0; oral glucose tolerance test (OGGT) ≥11.1, HbA1c≥6.5)), 39 patients had prediabetes (FPG 5.6–6.9, OGGT – 7.8–11.0, HbA1c5.7–6.4%). The level of IL-10 was increased in patients with AH and prediabetes (90.8 (90.6–91.1), P<0.05). At the same time, patients with AH combined with type 2 DM were characterized by the decrease of IL-10 level (77.4 (75.5–79.3), P<0.05). According to the results of discriminant analysis, aimed to search for signs that allow to differentiate prediabetes from T2DM, it was found that IL-10 and HbA1c are exactly the required signs:
– T2DM=5216×IL-10+2,643×HbA1c−211,174;
– Prediabetes=6114×IL-10+3,059×HbA1c−29,053.
Conclusion |
The obtained data suggest that increase of IL-10 level in patients with arterial hypertension and prediabetes can serve as a protective response and an early marker of carbohydrate metabolism disorders. Changes in IL-10 and HbA1c levels are the most important prognostic factors that reflect the development of carbohydrate metabolism disorders in patients with hypertension.
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Vol 12 - N° 1
P. 139 - janvier 2020 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.