Health-related quality of life correlates with time in therapeutic range in children under anticoagulants with INR self-monitoring - 06/01/20
Résumé |
Background |
In paediatrics, managing oral anticoagulant therapy with vitamin K antagonists (VKA) remains challenging. This study aimed to assess the correlation between time in therapeutic range (TTR) and quality of life (QoL) in children participating in a non-selective INR self-monitoring VKA-educational program.
Methods |
Children aged from 2 to 18 years under VKA therapy were eligible for this prospective multicentre study. Clinical and demographic data were collected. Health-related QoL was assessed using the PedsQL 4.0 questionnaire. Correlations between QoL scores and TTR were measured.
Results |
A total of 121 children were included in the study (mean age 9.6±4.9 years old). Cardiac conditions represented the predominant indication for VKA. The mean TTR was 0.78±0.15, overall, and 0.76±0.24 over the 3-month period before QoL assessment. The mean total QoL score was 76.2±18 in self-reports, 71.4±22 in mother-reports, and 73.5±19 in father-reports. The TTR correlated with the total QoL scores, in self-reports (r=0.22, P=0.04), mother-reports (r=0.23, P=0.02), and father-reports (r=0.28, P=0.02). The TTR predominantly correlated with school functioning in self-reports (r=0.38, P=0.002) and mother-reports (r=0.40, P<0.01), and with physical functioning in father-reports (r=0.28, P=0.02).
Conclusion |
TTR correlated with QoL in children participating in a non-selective INR self-monitoring VKA-educational program. Regular assessment of QoL in patient education programs participates in understanding the concerns and needs of patients.
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Vol 12 - N° 1
P. 168 - janvier 2020 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.