Acute coronary syndrome (ACS) is a primary cause of morbidity and mortality in the world. Arterial stiffness has been shown to be a predictor of cardiovascular events and mortality.

To assess the association between markers of arterial stiffness and multivessel disease after ACS.

This prospective study was conducted from April 2017 to March 2018 in a single cardiac center. A total of 275patients who were referred for first ACS were enrolled. Arterial stiffness was assessed by carotid to femoral pulse wave velocity (cfPWV), central pulse pressure (cPP) and augmentation index using SphygmoCor®XCEL.

The mean age was 56.4±10.6years. Tobacco smoking and diabetes were present in 56.4% and 41.8% of patients, respectively. ST segment elevation myocardial infarction was predominant (54.5%) and 47.6% of patients had multivessel disease. This study showed that cfPWV (OR=1.272; 95%IC [1.090;1.483]; P=0.002) and cPP (OR=1.071; 95%IC [1.024;1.121]; P=0.003) were the two independent predictors of multivessel disease. The cfVOP threshold for predicting multivessel disease was 12.65m/s (sensitivity of 48.1% and specificity of 76.4%).

Arterial stiffness measured by cfPWV and cPP may reflect the extent of coronary artery disease after ACS.